2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111346R
    1-Linoleoyl Glycerol (Standard) 2277-28-3
    1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
    1-Linoleoyl Glycerol (Standard)
  • HY-111827R
    S-1-Propenyl-L-cysteine (Standard) 52438-09-2
    S-1-Propenyl-L-cysteine (Standard) is the analytical standard of S-1-Propenyl-L-cysteine. This product is intended for research and analytical applications. S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway. S-1-Propenyl-L-cysteine is orally active.
    S-1-Propenyl-L-cysteine (Standard)
  • HY-112581A
    5-Methoxyuridine-5'-triphosphate 847649-65-4 98%
    5-Methoxyuridine-5'-triphosphate is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Methoxyuridine-5'-triphosphate
  • HY-112868A
    ABH 222638-65-5 98%
    ABH is an orally active arginase inhibitor (Ki = 8.5 nM). ABH promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1). ABH improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis.
    ABH
  • HY-112942B
    CMP-Sialic acid disodium 149007-28-3 98%
    CMP-Sialic acid (CMP-Neu5Ac) sodium is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.
    CMP-Sialic acid disodium
  • HY-113004R
    3-Hydroxyvaleric acid (Standard) 10237-77-1
    3-Hydroxyvaleric acid (Standard) is the analytical standard of 3-Hydroxyvaleric acid. This product is intended for research and analytical applications. 3-Hydroxyvaleric acid is a five-carbon ketone body byproduct that can undergo an anaplerotic reaction to replenish the intermediates of the tricarboxylic acid cycle. 3-Hydroxyvaleric acid is one of the important monomers for the synthesis of polyhydroxyalkanoates (PHA). PHA is a type of biodegradable plastic that is widely used in environmentally friendly packaging, disposable products, and medical materials.
    3-Hydroxyvaleric acid (Standard)
  • HY-113005R
    Glutarylcarnitine (Standard) 102636-82-8 98%
    Glutarylcarnitine (Standard) is the analytical standard of Glutarylcarnitine. This product is intended for research and analytical applications. Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.
    Glutarylcarnitine (Standard)
  • HY-113020R
    21-Hydroxypregnenolone (Standard) 1164-98-3
    21-Hydroxypregnenolone (Standard) is the analytical standard of 21-Hydroxypregnenolone (HY-113020). This product is intended for research and analytical applications. 21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM.
    21-Hydroxypregnenolone (Standard)
  • HY-113068R
    (rel)-β-Tocopherol (Standard) 148-03-8
    (rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.
    (rel)-β-Tocopherol (Standard)
  • HY-113068S
    β-Tocopherol-d3 936230-75-0 98%
    β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.
    β-Tocopherol-d3
  • HY-113075R
    1,5-Anhydrosorbitol (Standard) 154-58-5 98%
    1,5-Anhydrosorbitol (Standard) is the analytical standard of 1,5-Anhydrosorbitol. This product is intended for research and analytical applications. 1,5-Anhydrosorbitol is a short-term marker for glycemic control.
    1,5-Anhydrosorbitol (Standard)
  • HY-113096S
    Prostaglandin D1-d4 98%
    Prostaglandin D1-d4 (PGD1-d4) is deuterium labeled Prostaglandin D1. Prostaglandin D1 is a prostanoid which causes contractile and relaxant on isolated human pial arteries, it is also an inhibitor of ADP-induced platelet aggregation with an IC50 value of 320 ng/ml. Prostaglandin D1 can be used for metabolic research.
    Prostaglandin D1-d4
  • HY-113113S
    13,14-Dihydro PGE1-d4 2705226-66-8 98%
    13,14-Dihydro PGE1-d4 (13,14-Dihydroprostaglandin E1-d4) is deuterium labeled 13,14-Dihydro PGE1. 13,14-Dihydro PGE1 is a metabolite of PGE1 (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID50 = 10.8 ng/mL platelet rich plasma).
    13,14-Dihydro PGE1-d4
  • HY-113126R
    3-Hydroxyisobutyric acid (Standard) 2068-83-9 98%
    3-Hydroxyisobutyric acid (Standard) is the analytical standard of 3-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.
    3-Hydroxyisobutyric acid (Standard)
  • HY-113130R
    Eicosadienoic acid (Standard) 2091-39-6 98%
    Eicosadienoic acid (Standard) is the analytical standard of Eicosadienoic acid. This product is intended for research and analytical applications. Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.
    Eicosadienoic acid (Standard)
  • HY-113138R
    3-Methyluridine (Standard) 2140-69-4 98%
    3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance.
    3-Methyluridine (Standard)
  • HY-113159A
    Docosapentaenoic acid (22n-3) sodium 2983837-44-9 98%
    Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. Docosapentaenoic acid 22n-3 sodium has inhibitory activity against α-amylase and α-glucosidase, with IC50s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 sodium increases cell vitality. Docosapentaenoic acid 22n-3 sodium has a weak anti-inflammatory effect.
    Docosapentaenoic acid (22n-3) sodium
  • HY-113168R
    Butyrylcarnitine (Standard) 25576-40-3 98%
    Butyrylcarnitine (Standard) is the analytical standard of Butyrylcarnitine (HY-113168). This product is intended for research and analytical applications. Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer.
    Butyrylcarnitine (Standard)
  • HY-113202S
    Stearoyl-L-carnitine-d3 1021439-31-5 98%
    Stearoyl-L-carnitine-d3 is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2.
    Stearoyl-L-carnitine-d3
  • HY-113210R
    Hydroxyphenylacetylglycine (Standard) 28116-23-6 98%
    Hydroxyphenylacetylglycine (Standard) is the analytical standard of Hydroxyphenylacetylglycine. This product is intended for research and analytical applications. Hydroxyphenylacetylglycine is an acyl glycine, and an endogenous human metabolite.
    Hydroxyphenylacetylglycine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity